mental-post: Drugs

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The pancreas produces Insulin.

Insulin stops the use of fat as an energy source by inhibiting the release of glucagon. With the exception of the metabolic disorder diabetes mellitus and metabolic syndrome, insulin is provided within the body in a constant proportion to remove excess glucose from the blood, which otherwise would be toxic. When blood glucose levels fall below a certain level, the body begins to use stored sugar as an energy source through glycogenolysis, which breaks down the glycogen stored in the liver and muscles into glucose, which can then be utilized as an energy source. As a central metabolic control mechanism, its status is also used as a control signal to other body systems (such as amino acid uptake by body cells). In addition, it has several other anabolic effects throughout the body.

Insulin is produced in the pancreas and released when any of several stimuli are detected. These stimuli include ingested protein and glucose in the blood produced from digested food. Carbohydrates can be polymers of simple sugars or the simple sugars themselves. If the carbohydrates include glucose, then that glucose will be absorbed into the bloodstream and blood glucose level will begin to rise. In target cells, insulin initiates a signal transduction, which has the effect of increasing glucose uptake and storage. Finally, insulin is degraded, terminating the response.

This fish causes hallucinations when eaten and were used as a recreational drug by the Roman Empire.

Salema porgy, is a species of bream, recognisable by the golden stripes that run down the length of its body, and which can cause hallucinations when eaten. It is relatively common off the coasts of South Africa, Tenerife, Malta and Cyprus, but has been occasionally been found as far north as Great Britain.

Sarpa salpa was reportedly consumed as a recreational drug during the time of the Roman empire. The fish became widely known for its psychoactivity following widely publicized articles in 2006, when two men ingested it at a Mediterranean restaurant and began to perceive many auditory and visual hallucinogenic effects. These hallucinations, described as frightening, were reported to have occurred minutes after the fish was ingested and had a total duration of 36 hours.

Ichthyoallyeinotoxism, or hallucinogenic fish poisoning is common in other species of fish but not in Sarpa salpa, which is not normally psychoactive. It is, in fact, often served as a dish at seafood restaurants in the Mediterranean area. It is presently believed that the fish ingests a particular algae or phytoplankton which renders it hallucinogenic. The effects described are similar to those of indole tryptaminepsychedelics.

Pablo Escobar's drug cartel use to spend $2500 a month on rubber bands to wrap their cash with

In The Accountant’s Story, Pablo’s brother and accountant, Roberto Escobar, discusses the means by which Pablo rose from middle class simplicity and obscurity to become one of the world’s wealthiest men. At the height of its power, the Medellín drug cartel was smuggling fifteen tonnes of cocaine a day, worth more than half a billion dollars, into the United States. According to Roberto, he and his brother’s operation spent $2500 a month purchasing rubber bands to wrap the stacks of cash, storing most of it in their warehouses; 10% had to be written-off due to “spoilage” by rats who crept in at night and nibbled on the hundred dollar bills.

In 1975, Escobar started developing his cocaine operation. He even flew a plane himself several times, mainly between Colombia and Panama, to smuggle a load into the United States. When he later bought fifteen new and bigger airplanes (including a Learjet) and six helicopters, he decommissioned the plane and hung it above the gate to his ranch at Hacienda Napoles. His reputation grew after a well known Medellín dealer named Fabio Restrepo was murdered in 1975 ostensibly by Escobar, from whom he had purchased fourteen kilograms (14kg). Afterwards, all of Restrepo’s men were informed that they were working for Pablo Escobar. In May 1976, Escobar and several of his men were arrested and found in possession of 39 pounds (18 kg) of white paste after returning to Medellín with a heavy load from Ecuador. Initially, Pablo tried unsuccessfully to bribe the Medellín judges who were forming the case against him. Instead, after many months of legal wrangling, Pablo had the two arresting officers bribed and the case was dropped. It was here that he began his pattern of dealing with the authorities by either bribing them or killing them. Roberto Escobar maintains Pablo fell into the business simply because contraband became too dangerous to traffic. There were no drug cartels then and only a few drug barons, so there was plenty of business for everyone. In Peru, they bought the cocaine paste, which they refined in a laboratory in a two-story house in Medellín. On his first trip, Pablo bought a paltry £30 worth of paste in what was to become the first step towards the building of his empire. At first, he smuggled the cocaine in old plane tires and a pilot could earn as much as £500,000 a flight depending on how much he could smuggle.

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