Wood frogs can be frozen solid and then thawed, and continue living. They use the glucose in their body to protect their vital organs while they are in a frozen state

The wood frog has garnered attention by biologists over the last century because of its freeze tolerance, relatively great degree of terrestrialism (for a Ranid), interesting habitat associations (peat bogs, vernal pools, uplands), and relatively long-range movements. The ecology and conservation of the wood frog has attracted a great deal of research attention in recent years. This may be because they are often considered “obligate” breeders in ephemeral wetlands (sometimes called “vernal pools”) that are themselves more imperiled than the species that breed in them (see below). The wood frog is the state amphibian of New York.

Similar to other northern frogs that hibernate close to the surface in soil and/or leaf litter, wood frogs can tolerate the freezing of their blood and other tissues. Urea is accumulated in tissues in preparation for overwintering, and liver glycogen is converted in large quantities to glucose in response to internal ice formation. Both urea andglucose act as “cryoprotectants” to limit the amount of ice that forms and to reduce osmotic shrinkage of cells. Frogs can survive many freeze/thaw events during winter if no more than about 65% of the total body water freezes.